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Acemannan


What is Acemannan?

Acemannan is a uniquely structured, biodegradable polysaccharide containing acetylated polymannose, found in the inner leaf gel of the aloe vera plant (in a wide variety of molecular weights). It is mainly composed of mannose (84.9%), glucose (7.2%), and galactose (3.9%), with backbone of (1→4)-linked mannose and glucose.

A little history, first…

It wasn’t until the mid-1980’s when Dr. Bill McAnalley, a research pharmacologist, discovered and stabilized aloe’s immune-optimizing molecule. It was named Acemannan. Carrington Labs was created to commercialize the first stabilized Acemannan. Over $100M was spent on the validation of its safety and unlimited health benefits. Over 30 patents on Acemannan were granted on its stabilizing process and its wide range of pharmacological uses (first patent #5308838). While Acemannan doesn’t heal anything, it allows the body to function the way it was designed to.

However, there is a tricky part to reaping the incredible benefits of Acemannan, it is only active for 24 hours once the leaf is broken. 99% of aloe vera juices and supplements tested did not contain any immune modulating Acemannan fractions. The extraction and stabilization technique is critical to ensure the highest amount of bioactive Acemannan fractions.

If you are struggling with a chronic health issue or autoimmune disorder you really want to KEEP READING…

The filtration technique is another critical manufacturing step. This part of the process, if not done correctly, can damage the active molecules or allow in less than ideal weight fractions. Acemannan with molecular weights of 50-400 kilodaltons (kDa) make the biggest impact on our immune system’s functions of defense and repair.

Acemannan’s unique structure binds to macrophage cell-surface receptors and activates their broad range of defense and repair functions. Macrophage are the master regulators of our immune system. No other molecule in nature or medicine has shown the capacity to function as efficiently as Acemannan in providing this benefit. *

What are the benefits?

Acemannan has many benefits!

ANIMAL HEALTH
Autoimmune
BONE HEALTH
COLLAGEN & SKIN
Immune Support
Inflammation
KIDNEY HEALTH
Metabolism
Neuroprotection
Nutrient Absorption
ORAL HEALTH
PREBIOTIC
Radiation Protection
Thyroid Health
Vascular Health

In addition, many people taking Acemannan have noted other improvements.

Allergies

Supporting Research/Articles – General Usage of Acemannan

Supporting Research/Studies – Specific Acemannan Application

And there is another important element… glutathione! Acemannan can increase the production of your bodies only primary antioxidant, glutathione, as well as reduce its depletion from oxidative stress… by up to 50%* in both cases.

Blood Sugar
GUt Health
Liver Support

Supporting Research/Articles – Glutathione

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  • Cellular Fuel Source: Its high mannose and glucose content provides a direct energy source for cells.
  • Insulin Regulation: The prebiotic properties of Acemannan might contribute to regulating insulin levels, aiding in proper glucose metabolism.
  • Anti-inflammatory Action: Reduced inflammation, achieved through Acemannan’s properties, improves the overall metabolic environment.
  • Antioxidant Defense: By mitigating free radical damage, acemannan helps maintain cellular homeostasis and optimize protein function for efficient metabolism.
  • Fat Metabolism Modulation: Acemannan’s anti-inflammatory and anti-diabetic properties may protect against chronic inflammation, a potential contributor to obesity and metabolic syndrome. Its prebiotic activity might reduce fat cells and decrease dietary lipid absorption. Additionally, it may regulate insulin levels and glucose transport, both crucial for proper fat metabolism.


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Mannose, a sugar only found in aloe vera and breast milk, is a key ingredient in Acemannan. Certain autoimmune responses and conditions can go into remission during pregnancy, due to the high levels of mannose in the blood, resulting in improved immune function.


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Acemannan can lessen the body’s predisposition to allergies, including autoimmune reactions through its ability to reduce inflammation related to allergies. Both oral and topical Acemannan has helped people with plant allergies, to include hay fever, by reducing symptoms like itching, congestion, and headaches. Topically it has been used to reduce the severity and healing time of poison ivy rashes in humans and animals. Additionally, chemical exposure can cause breathing issues due to fumes, etc., and some have found relief after taking oral Acemannan (800mg/day).


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By calming inflammation in key organs, Acemannan may improve insulin sensitivity, leading to better blood sugar control. Acemannan’s calming may reduce cravings and promote satiety, potentially helping maintain steady blood sugar levels. Studies suggest benefits like lower fasting blood sugar and HbA1c (a measure of long-term blood sugar control) in diabetic patients or animal models.


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Acemannan can stimulate the immune system by increasing the activity of immune cells like macrophages and lymphocytes, and increases production of stem cells by 300% – 400% to replace diseased cells.* Additionally, by reducing inflammation, Acemannan could indirectly create a more favorable environment for the immune system to function.


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The gut’s role in digestion, immunity, and even mood regulation through its connection to the brain via the nervous system is central. Acemannan can reduce inflammation in the nervous system, boost immunity by stimulating antibody production, improve nutrient absorption, balancing pH, maintain proper ratio of gut bacteria, enhance communication between the brain and gut, support a healthy gut lining by reducing inflammation and promoting beneficial bacteria, and modulate neurotransmitters linked to mood (e.g., serotonin, dopamine, GABA).


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In vitro (lab) and in vivo (animal) studies suggest Acemannan may reduce inflammation by influencing immune cell activity and cytokine production (signaling molecules involved in inflammation). These studies propose mechanisms like increased production of anti-inflammatory mediators and decreased production of pro-inflammatory ones.


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Studies suggest potential benefits of aloe vera (which contains Acemannan) for hypothyroidism (underactive thyroid).


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The liver is the primary producer of glutathione, a crucial antioxidant that helps the body detoxify harmful substances and protects cells from damage. Studies suggest glutathione may offer several benefits for liver health, including reduced oxidative stress (helps neutralize free radicals, which can damage liver cells), improved detoxification (aids in the breakdown and elimination of toxins, including alcohol, drugs, and pollutants), and reduced inflammation, potentially benefiting conditions like non-alcoholic fatty liver disease (NAFLD).


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Acemannan exhibits antioxidant activity, which could help protect brain cells from damage caused by free radicals. Some studies suggest Acemannan might have anti-inflammatory properties, and chronic inflammation is considered a factor in several neurodegenerative diseases.


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Acemannan might possess radioprotective properties, meaning it could help protect healthy cells from damage caused by radiation exposure. Studies show benefits of increased survival rates after radiation exposure, improved blood cell counts and immune function, and reduced inflammation and tissue damage. The believed mechanisms for these benefits are upregulating hematopoietic stem cells (crucial for blood cell production), stimulating the immune system to fight off infections (more common after radiation exposure), and reducing oxidative stress caused by radiation (which can damage cells).


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Prebiotics are non-digestible food ingredients that promote the growth of beneficial bacteria in the gut microbiome. They act as a food source for these beneficial bacteria, stimulating their growth and activity. Studies have shown that Acemannan can stimulate the growth of beneficial bacteria like Bifidobacterium and Lactobacillus. These bacteria ferment Acemannan, potentially leading to the production of short-chain fatty acids (SCFAs). SCFAs aid in the absorption of minerals like calcium and magnesium, reduce inflammation in the gut lining, provide energy for colon cells, and contribute to a healthy gut immune system.


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Acemannan can help increase the bioavailability of nutrients, specifically vitamins (e.g., B, C, and E). Additionally, studies have shown that it significantly increase plasma oxygen radical absorbance capacity (ORAC) and fermented Acemannan in the gut can potentially lead to the production of short-chain fatty acids (SCFAs). SCFAs aid in the absorption of minerals like calcium and magnesium.


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Beneficial bacteria in the gut play key role in the overall gut health, as well as potentially influence collagen metabolism through production and absorption. Chronic inflammation can contribute to collagen breakdown, leading to wrinkles or weakened tissues. Addressing both gut health and chronic inflammation with Acemannan is made primarily of mannose and glucose, both of which are essential for extracellular matrix synthesis. These molecules stimulate healthy production of collagen and glycosaminoglycans (bonding agent for bone structures), as well as increase numbers of bone marrow stem cells (BMSCs).


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Acemannan causes the activation of macrophages by increasing the level of nitric oxide synthase at the level of transcription. Nitric oxide (NO) plays a critical role in maintaining vascular health. NO acts as a potent vasodilator, meaning it relaxes the smooth muscle cells lining blood vessel walls. This relaxation allows the blood vessels to widen, increasing blood flow and reducing blood pressure. This improved blood flow ensures proper delivery of oxygen and nutrients to tissues throughout the body. NO helps prevent blood clots by inhibiting the clumping together (aggregation) of platelets, blood cells involved in clotting. This reduces the risk of blood clots forming and blocking blood flow in arteries. NO possesses anti-inflammatory properties, helping to reduce inflammation within the blood vessel walls. Chronic inflammation can damage blood vessels and contribute to atherosclerosis (plaque buildup). NO also plays a role in cell growth, survival, and communication within the vascular system.


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Acemannan is made primarily of mannose and glucose, both of which are essential for extracellular matrix (ECM) synthesis. These molecules stimulate healthy production of collagen and glycosaminoglycans (bonding agent for bone structures), as well as increase numbers of bone marrow stem cells (BMSCs). These BMSCs can proliferate into osteoblasts (bone-forming cells) with increased ECM synthesis helping to improve and maintain healthy bones.


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In vitro (lab) studies suggest Acemannan might have some antibacterial activity against certain oral pathogens like Streptococcus mutans, a bacterium associated with cavities. Similar to its potential effects elsewhere in the body, Acemannan might have anti-inflammatory properties that could benefit gum health by reducing inflammation in the gums (gingivitis). Studies have shown its efficacy for regeneration of periodontal tissues (ligament cells, pulp) and accelerating cementum (alveolar bone).


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Acemannan may assist the kidneys by reducing the absorption of oxalates. Oxalates are naturally occurring compounds found in some foods and can also be produced by the body. High oxalate levels can contribute to the formation of kidney stones in some individuals. In addition to helping with oxalates, the other properties of Acemannan, improved insulin levels, antioxidant, and anti-inflammatory properties all contribute to proper metabolic function and overall kidney health.


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Studies indicate that the use of Acemannan in treating animals to be beneficial. One dataset suggests that Acemannan Immunostimulant may be an effective adjunct to surgery and radiation therapy where they treated over a dozen animals, with a poor prognosis for survival, and resulted in greater than 50% surviving tumor-free for over a year.

Why ALOVÉA?

The foundational strategy for formulating the most efficacious health-building product was to secure the exclusive rights to the world’s best-in-class ingredients and combing with our proprietary Acemannan extract. Dr. Santiago Rodriguez developed a new extraction process that provides the highest level of immune-modulating fractions of aloe vera Acemannan. He donated this technology to the HOPE Movement. It is known as Alovéa AE (Acemannan extract).

[1] The majority of all aloe-based products are NOT stabilized and contain little to no Acemannan.

[2] Stabilized aloe products contain an average of 4% immune-modulating fractions of Acemannan per gram.

[3] Only Alovéa Immun contains at least 18% immune-modulating fractions of Acemannan per gram.

Fact Sheet

Did you know?

It would take drinking eight (8) gallons of aloe vera juice to get the same level of Acemannan as one serving of Alovéa Immun!

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