What is CycloDextrin Delivery System?
Cyclodextrins are glucose macrocycles whose inclusional capabilities towards non-polar solutes can be modulated with the help of other macrostructures. The incorporation of cyclodextrin moieties into larger structures produces five types of new materials: crosslinked networks, functionalized chains, amphiphilic cyclodextrins, polyrotaxanes, and nanocomposites. Applications using covalently-attached cyclodextrins include the nutraceutical industry.
More simply, cyclodextrins (CDs) are cyclic oligosaccharides, meaning they are ring-shaped sugar molecules. They have a unique structure with a hydrophobic (water-fearing) interior cavity and a hydrophilic (water-loving) exterior surface. The hydrophobic cavity of CDs can act as a host molecule, encapsulating poorly soluble molecules. This can significantly improve the molecule’s solubility in water, making it more easily absorbed by the body. The hydrophilic exterior allows the CD-molecule complex to remain dispersed in aqueous solutions.
What are the benefits?
- Higher Bioavailability: Enable the delivery of valued molecules to the intended destination before loss/removal from other bio-systems (wasting).
- Enhanced Solubility: As mentioned above, CDs can significantly improve the solubility of poorly soluble molecules, making them more bioavailable (better absorbed by the body).
- Improved Stability: CDs can protect molecules from degradation caused by light, heat, or other environmental factors.
- Modified Release: By controlling the size and structure of the CD cavity, researchers can design systems for sustained or targeted molecule release.
- Side Effect Reduction: By improving molecule solubility and targeting delivery, CDs can potentially reduce “side effects” associated with the introduction of the new molecule(s).
Why ALOVรA?
Our patented delivery technology uses cyclodextrins (CDโs), cyclic oligosaccharides, that have a truncated cone shape with a hydrophilic outer wall. Because of this unique architecture, CDโs are soluble in water and can simultaneously host lipophilic (oil) guests molecules. This allows for multiple higher times bioavailability.
Did you know?
Cyclodextrin polymers have been used since the 1960’s for food packaging, retention of aromas, and gene therapy. In the 1990’s “nanosponges” were introduced due to their nanoporous, sponge-like structure.